SCHEMBL7910646

SCHEMBL7910646

COC(=O)c1ccc(OCc2ccc(Cl)cc2)cc1OCc1ccc(Cl)cc1

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.63
MAOA P21397 5/20 0.63
NPC1 O15118 1/20 0.59
RAB9A P51151 1/20 0.59
FFAR4 Q5NUL3 1/20 0.54
NR4A2 P43354 2/20 0.51
HDAC1 Q13547 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
MRGPRX4 Q96LA9 1/20 0.50
PPARG P37231 1/20 0.48
KDM4E B2RXH2 2/20 0.48
MEN1 O00255 1/20 0.48
LMNA P02545 1/20 0.48
POLB P06746 1/20 0.48
GAA P10253 1/20 0.48
MAPT P10636 1/20 0.48
KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7910948 0.95 MAOB (0.57) MAOBMAOANPC1RAB9AFFAR4
SCHEMBL7911112 0.95 MAOB (0.57) MAOBMAOANPC1RAB9AFFAR4
SCHEMBL7911129 0.89 MAOB (0.75) MAOBMAOANPC1RAB9ANR4A2
SCHEMBL3962253 0.86 MAOB (0.61) MAOBNPC1RAB9AFFAR4NR4A2
SCHEMBL29032389 0.84 SMPD1 (0.53) NPC1RAB9AFFAR4HDAC8KDM4E
SCHEMBL7914707 0.84 MAOA (0.63) MAOBMAOANR4A2MRGPRX4KMT2A
SCHEMBL7909052 0.84 MRGPRX4 (0.53) MAOBNPC1RAB9AFFAR4MRGPRX4
SCHEMBL31451790 0.84 KDM4E (0.57) MAOBMAOANPC1RAB9ANR4A2
SCHEMBL7907439 0.84 MAOB (0.56) MAOBNPC1RAB9AFFAR4HDAC8
SCHEMBL21434703 0.83 PTGER1 (0.57) NPC1RAB9AFFAR4MRGPRX4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211234-B1 BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID RHONE-POULENC RORER LIMITED (GB) 2001-04-03 US disclosed
EP-0728128-B1 SUBSTITUTED PHENYL COMPOUNDS RHONE POULENC RORER LTD (GB) 1998-09-16 EP disclosed
EP-0728128-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1996-08-28 EP disclosed
WO-1995013262-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1995-05-18 WO disclosed