SCHEMBL3962253

SCHEMBL3962253

COC(=O)c1ccc(OCc2ccccc2)cc1OCc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.61
FFAR4 Q5NUL3 1/20 0.56
NPC1 O15118 4/20 0.54
RAB9A P51151 4/20 0.54
SMN1; SMN2 Q16637 4/20 0.54
LMNA P02545 1/20 0.54
HPGD P15428 1/20 0.54
ALDH1A1 P00352 2/20 0.52
KDM4E B2RXH2 1/20 0.52
GAA P10253 1/20 0.52
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
PARP15 Q460N3 1/20 0.50
NR4A1 P22736 1/20 0.50
NR4A2 P43354 1/20 0.50
NR4A3 Q92570 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7907439 0.95 MAOB (0.56) MAOBFFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL21924287 0.94 MAOB (0.58) MAOBFFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL3191667 0.94 MAOB (0.58) MAOBFFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL1763456 0.93 MAOB (0.57) MAOBFFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL3201763 0.93 MAOB (0.57) MAOBFFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL11557673 0.93 KDM4E (0.60) MAOBFFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL7911112 0.92 MAOB (0.57) MAOBFFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL7910894 0.92 FFAR4 (0.65) MAOBFFAR4LMNAKMT2ANR4A2
SCHEMBL7910948 0.92 MAOB (0.57) MAOBFFAR4NPC1RAB9ASMN1; SMN2
SCHEMBL7909189 0.92 MAOB (0.53) MAOBFFAR4NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3710462-B1 BRARTEMICIN ANALOGUES VICTORIA LINK LTD (NZ) 2026-05-13 EP disclosed
US-20230139366-A1 BRARTEMICIN ANALOGUES VICTORIA LINK LIMITED (NZ) 2023-05-04 US disclosed
US-20230139366-A1 BRARTEMICIN ANALOGUES VICTORIA LINK LIMITED (NZ) 2023-05-04 US disclosed
US-11510980-B2 Brartemicin analogues VICTORIA LINK LTD. (NZ) 2022-11-29 US disclosed
US-11236053-B2 NADPH oxidase inhibitors and uses thereof EMORY UNIVERSITY (US) 2022-02-01 US disclosed
US-20210177965-A1 BRARTEMICIN ANALOGUES VICTORIA LINK LIMITED (NZ) 2021-06-17 US disclosed
US-20210177965-A1 BRARTEMICIN ANALOGUES VICTORIA LINK LIMITED (NZ) 2021-06-17 US disclosed
EP-3710462-A1 BRARTEMICIN ANALOGUES Victoria Link Limited (NZ) 2020-09-23 EP disclosed
US-20200270214-A1 NADPH Oxidase Inhibitors and Uses Thereof UNIV EMORY (US) 2020-08-27 US disclosed
WO-2019023448-A1 NADPH OXIDASE INHIBITORS AND USES THEREOF EMORY UNIVERSITY (US) 2019-01-31 WO disclosed
EP-2081891-A2 PHARMACEUTICAL COMPOUNDS HAVING HSP90 INHIBITORY OR MODULATING ACTIVITY Astex Therapeutics Limited (GB) 2009-07-29 EP disclosed
WO-2008044027-A2 PHARMACEUTICAL COMPOUNDS HAVING HSP90 INHIBITORY OR MODULATING ACTIVITY ASTEX THERAPEUTICS LIMITED (GB) 2008-04-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230139366-A1 BRARTEMICIN ANALOGUES RXFP1, RXFP2, RXFP4 MAOB 4572/4885FFAR4 627/4885NPC1 4100/4885
US-20200270214-A1 NADPH Oxidase Inhibitors and Uses Thereof NOX1, NOX3, NOX5 MAOB 138/4885FFAR4 1596/4885NPC1 2534/4885
US-20210177965-A1 BRARTEMICIN ANALOGUES RXFP1, RXFP2, CMKLR1 MAOB 4537/4885FFAR4 735/4885NPC1 3983/4885
US-11236053-B2 NADPH oxidase inhibitors and uses thereof NOX1, NOX3, NOX5 MAOB 138/4885FFAR4 1596/4885NPC1 2534/4885
US-11510980-B2 Brartemicin analogues RXFP1, RXFP2, CMKLR1 MAOB 4537/4885FFAR4 735/4885NPC1 3983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.