Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751254 | 0.83 | P2RX7 (0.44) | P2RX7HPGDTSHRROCK2ROCK1 | |
| SCHEMBL91285 | 0.82 | TSHR (0.46) | P2RX7HPGDTSHRSMN1; SMN2TRPV1 | |
| SCHEMBL1750533 | 0.81 | ERCC1 (0.46) | P2RX7HPGDTSHRSMN1; SMN2TRPV1 | |
| SCHEMBL1751145 | 0.78 | TSHR (0.41) | P2RX7HPGDTSHRSMN1; SMN2TRPV1 | |
| SCHEMBL5392945 | 0.76 | SMN1; SMN2 (0.64) | HPGDTSHRSMN1; SMN2 | |
| SCHEMBL1751252 | 0.76 | P2RX7 (0.41) | P2RX7HPGDTSHRSMN1; SMN2 | |
| SCHEMBL78590 | 0.76 | EPHX2 (0.54) | P2RX7HPGDTSHRSMN1; SMN2EPHX2 | |
| SCHEMBL7927014 | 0.75 | P2RX7 (0.58) | P2RX7ROCK2ROCK1TRPV1NR3C1 | |
| SCHEMBL3272732 | 0.74 | P2RX7 (0.57) | P2RX7 | |
| SCHEMBL22537452 | 0.74 | P2RX7 (0.58) | P2RX7TSHRROCK2ROCK1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |