Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139259 | 0.86 | GAA (0.49) | CYP2D6ADRA2AADRA1AMAPK1GAA | |
| SCHEMBL9092422 | 0.83 | TSHR (0.58) | MAPK1GAAPTGS1PTGS2CA2 | |
| SCHEMBL7903986 | 0.81 | ADRA1A (0.60) | ADRA2AADRA1ABLMGAAPTGS1 | |
| SCHEMBL7913936 | 0.78 | GAA (0.48) | ADRA2AADRA1AGAAPTGS1PTGS2 | |
| SCHEMBL7903977 | 0.77 | ADRA1A (0.56) | ADRA2AADRA1ABLMGAAPTGS1 | |
| Methoxamine SCHEMBL4258097 | 0.76 | ADRA1A (1.00) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| Methoxamine SCHEMBL4258100 | 0.76 | ADRA1A (1.00) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| SCHEMBL5051458 | 0.76 | ADRA2A (0.71) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| Methoxamine SCHEMBL7786034 | 0.76 | ADRA1A (1.00) | CYP2D6ADRA2AADRA1AMEN1MAPK1 | |
| Methoxamine SCHEMBL146222 | 0.76 | ADRA1A (1.00) | CYP2D6ADRA2AADRA1AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842148-B1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SANOFI SYNTHELABO (FR) | 2000-12-20 | — | — | EP | claimed |
| US-6214882-B1 | Benzenesulphonamide derivatives, preparation thereof and therapeutical uses thereof | SYNTHELABO (FR) | 2001-04-10 | — | — | US | disclosed |
| EP-0842148-B1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SANOFI SYNTHELABO (FR) | 2000-12-20 | — | — | EP | disclosed |