Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | SCN1A | P35498 | 1/20 | 0.61 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.61 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methoxamine SCHEMBL4258100 | 1.00 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL34158 | 1.00 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL5172511 | 1.00 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL29763696 | 1.00 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL5172508 | 1.00 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL1043727 | 1.00 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL146222 | 1.00 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL7786034 | 1.00 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL146117 | 0.98 | MEN1 (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL9614282 | 0.98 | MEN1 (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042275-A1 | NOVEL PLASMIDS AND UTILIZATION THEREOF | DAIICHI FINE CHEMICAL CO., LTD. (JP) | 2009-02-12 | — | — | US | disclosed |
| EP-1273665-B1 | PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS | DAIICHI FINE CHEM CO LTD (JP) | 2007-05-16 | — | — | EP | disclosed |
| US-6835559-B2 | Process for the production of optically active β-amino alcohols | DAIICHI FINE CHEMICAL CO., LTD. (JP) | 2004-12-28 | — | — | US | disclosed |
| US-20040091981-A1 | Process for the production of optically active beta-amino alcohols | DAIICHI FINE CHEMICAL CO., LTD. (JP) | 2004-05-13 | — | — | US | disclosed |
| EP-1273665-A1 | PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS | Daiichi Fine Chemical Co., Ltd. (JP) | 2003-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042275-A1 | NOVEL PLASMIDS AND UTILIZATION THEREOF | COASY, BLVRB, TKT | ADRA1A 2061/4885ADRA2A 2648/4885CYP2D6 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.