SCHEMBL7912924

SCHEMBL7912924

Cc1csc(-c2ccc(-c3nc(C)cs3)cc2)n1.Cc1nc(-c2ccccc2)c(-c2ccccc2)s1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 8/20 0.56
PTGS1 P23219 4/20 0.56
FFAR4 Q5NUL3 1/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2C9 P11712 2/20 0.47
SREBF2 Q12772 1/20 0.47
CYP2E1 P05181 1/20 0.47
CYP2A6 P11509 1/20 0.47
CYP2B6 P20813 1/20 0.47
ALOX5 P09917 2/20 0.46
ALDH1A1 P00352 3/20 0.44
CYP1A2 P05177 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2C19 P33261 2/20 0.44
MAPT P10636 2/20 0.44
KDM4E B2RXH2 1/20 0.43
GAA P10253 1/20 0.43
MEN1 O00255 1/20 0.42
LMNA P02545 1/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL526264 0.83 PTGS2 (0.69) PTGS2PTGS1FFAR4CYP3A4CYP2C9
SCHEMBL14438067 0.81 CYP3A4 (0.61) CYP3A4CYP2C9SREBF2CYP2E1CYP2A6
SCHEMBL87128 0.81 CYP3A4 (0.65) CYP3A4CYP2C9SREBF2CYP2E1CYP2A6
SCHEMBL7840843 0.77 PTGS2 (0.65) PTGS2PTGS1FFAR4CYP3A4CYP2C9
SCHEMBL7839944 0.77 PTGS2 (0.65) PTGS2PTGS1FFAR4CYP3A4CYP2C9
SCHEMBL7841482 0.77 PTGS2 (0.65) PTGS2PTGS1FFAR4CYP3A4CYP2C9
SCHEMBL8198560 0.76 CYP3A4 (0.60) CYP3A4CYP2C9SREBF2CYP2E1CYP2A6
SCHEMBL7905176 0.74 CYP3A4 (0.58) CYP3A4CYP2C9SREBF2CYP2E1CYP2A6
SCHEMBL13740516 0.74 MAPK14 (0.55) PTGS2PTGS1FFAR4ALOX5ALDH1A1
SCHEMBL12245630 0.72 ALOX5 (0.69) PTGS2PTGS1CYP3A4CYP2C9SREBF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0872903-B1 Method for making hydrogen storage alloy powder and electrode comprising the alloy powder SHINETSU CHEMICAL CO (JP) 2001-10-04 EP disclosed
US-6277519-B1 QUENCHING AN ALLOY MELT; COMMINUTION SHIN-ETSU CHEMICAL CO., LTD. (JP) 2001-08-21 US disclosed
EP-0872903-A1 Method for making hydrogen storage alloy powder and electrode comprising the alloy powder Shin-Etsu Chemical Co., Ltd. (JP) 1998-10-21 EP disclosed