Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | DPYD | Q12882 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913210 | 1.00 | DHFR (0.48) | DHFRMPOADORA2AADORA1ADK | |
| SCHEMBL3822553 | 0.86 | DHFR (0.45) | DHFRMPODPYDFAAHMGLL | |
| SCHEMBL3817701 | 0.83 | DHFR (0.46) | DHFRMPODPYD | |
| SCHEMBL3818242 | 0.80 | LMNA (0.63) | DHFRADKLMNAP2RY6NT5E | |
| SCHEMBL21130861 | 0.74 | ADK (0.45) | ADKLMNA | |
| SCHEMBL2578281 | 0.74 | LMNA (0.57) | ADORA2AADORA1ADORA2BLMNA | |
| SCHEMBL16631213 | 0.74 | ADK (0.39) | ADORA1ADKLMNA | |
| SCHEMBL16631641 | 0.70 | ADK (0.43) | ADORA1ADK | |
| SCHEMBL8008108 | 0.70 | P2RY2 (0.54) | ADORA2AADORA1DPYDADORA2B | |
| SCHEMBL2579590 | 0.70 | LMNA (0.46) | ADORA2AADORA1ADORA2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882734-A2 | 5'-Deoxy-cytidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-09 | — | — | EP | claimed |
| US-6211166-B1 | COADMINISTERED WITH A 5-FLUOROURACIL DERIVATIVE; ANTICARCINOGENIC AGENTS | HOFFMAN-LA ROCHE INC. | 2001-04-03 | — | — | US | disclosed |
| US-6114520-A | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0882734-A2 | 5'-Deoxy-cytidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-09 | — | — | EP | disclosed |