Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 8/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 4/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229264 | 0.87 | GRM2 (0.47) | PTPN1GRM2YAP1ITGB3ITGA2B | |
| SCHEMBL7228413 | 0.86 | GRM2 (0.61) | PTPN1GRM2YAP1 | |
| SCHEMBL7236747 | 0.81 | GRM2 (0.49) | GRM2ITGB3ITGA2B | |
| SCHEMBL7229073 | 0.80 | GRM2 (0.45) | GRM2ITGB3ITGA2B | |
| SCHEMBL7913397 | 0.80 | GRM2 (0.45) | GRM2 | |
| SCHEMBL7239008 | 0.77 | ITGB3 (0.46) | PTPN1GRM2ITGB3ITGA2B | |
| SCHEMBL7229145 | 0.76 | YAP1 (0.46) | YAP1HRH2HRH1ITGB3ITGA2B | |
| SCHEMBL7228437 | 0.76 | YAP1 (0.42) | PTPN1YAP1KLK5HDAC8HRH2 | |
| SCHEMBL7228364 | 0.75 | YAP1 (0.48) | YAP1HRH2HRH1 | |
| SCHEMBL7237702 | 0.74 | HRH2 (0.47) | YAP1HRH2HRH1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |