Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CCKBR | P32239 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909444 | 0.87 | HTT (0.45) | HTTPOLBSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7909451 | 0.85 | ITGB3 (0.53) | HTTSMN1; SMN2KMT2A | |
| SCHEMBL8382626 | 0.84 | EPHX2 (0.48) | HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7909731 | 0.84 | ITGB3 (0.43) | HTTCCKBRSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7907914 | 0.81 | GAA (0.45) | HTTPOLBSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL670624 | 0.78 | CYP2C9 (0.55) | HTTPOLBCYP2C19ALDH1A1KMT2A | |
| SCHEMBL1441065 | 0.77 | HTT (0.43) | HTTAKT1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL1441038 | 0.77 | ALDH1A1 (0.50) | HTTPOLBSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL5231943 | 0.76 | KCNH2 (0.44) | HTTPOLBCYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL7906618 | 0.76 | HTT (0.49) | HTTCCKBRPOLBCYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |