Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | USP5 | P45974 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909451 | 0.90 | ITGB3 (0.53) | HTTITGB3ITGA2CHRM3SMN1; SMN2 | |
| SCHEMBL8382626 | 0.88 | EPHX2 (0.48) | HTTITGB3ITGA2CHRM3LMNA | |
| SCHEMBL7913422 | 0.87 | HTT (0.53) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7909731 | 0.84 | ITGB3 (0.43) | HTTITGB3ITGA2CHRM3L3MBTL1 | |
| SCHEMBL7907914 | 0.84 | GAA (0.45) | HTTITGB3ITGA2CHRM3L3MBTL1 | |
| SCHEMBL7909741 | 0.80 | F10 (0.41) | HTTITGB3ITGA2LMNAALDH1A1 | |
| SCHEMBL7907920 | 0.79 | ITGB3 (0.53) | HTTITGB3L3MBTL1LMNAALDH1A1 | |
| SCHEMBL8382617 | 0.78 | NAMPT (0.49) | HTTCHRM3L3MBTL1EPHX2POLB | |
| SCHEMBL8381170 | 0.78 | CHRM3 (0.49) | CHRM3L3MBTL1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8385665 | 0.77 | POLB (0.58) | HTTCHRM3LMNAALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |