Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092953 | 0.89 | EHMT2 (0.56) | ACHEPOLBEHMT2 | |
| SCHEMBL7097649 | 0.88 | EHMT2 (0.55) | CHEK1ACHEPOLBEHMT2 | |
| SCHEMBL7095121 | 0.78 | RXFP1 (0.42) | ALDH1A1GAAMAPK1EHMT2TSHR | |
| SCHEMBL4088385 | 0.77 | SYK (0.59) | SYKCHEK1POLBHTR2CHTR2B | |
| SCHEMBL12845584 | 0.76 | SYK (0.64) | SYKALDH1A1POLBHTR2CHTR2B | |
| SCHEMBL13849354 | 0.76 | SYK (0.64) | SYKALDH1A1POLBHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7092902 | 0.76 | MEN1 (0.40) | ALDH1A1GAAMAPK1CHEK1POLB | |
| SCHEMBL5564105 | 0.76 | MAOA (0.49) | KDM4EALDH1A1HTR2CHTR2BTSHR | |
| SCHEMBL7752192 | 0.75 | HTR7 (0.42) | ALDH1A1CHEK1BCHEACHEEHMT2 | |
| SCHEMBL3280903 | 0.74 | TSHR (0.47) | SYKKDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |