SCHEMBL7913644

SCHEMBL7913644

CCCCCC1=Nc2ncccc2C(=O)C1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
PTPN1 P18031 1/20 0.35
TRPV1 Q8NER1 1/20 0.33
KAT2B Q92831 1/20 0.33
NR1H2 P55055 1/20 0.33
NR1H3 Q13133 1/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
FAAH O00519 7/20 0.33
CDC25B P30305 1/20 0.32
S100A4 P26447 1/20 0.32
DAGLA Q9Y4D2 5/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2821603 0.78 PTPN1 (0.40) TDP1L3MBTL1PTPN1NR1H2NR1H3
SCHEMBL21065455 0.77 PTPN1 (0.42) TDP1L3MBTL1PTPN1NR1H2NR1H3
SCHEMBL472760 0.77 PTPN1 (0.42) TDP1L3MBTL1PTPN1NR1H2NR1H3
SCHEMBL2363208 0.74 CHEK1 (0.36) TDP1CDC25BS100A4
SCHEMBL8780480 0.74 PTPN1 (0.35) PTPN1NR1H2NR1H3PDE4APDE4B
SCHEMBL9694568 0.72 GAA (0.38) TDP1CDC25BS100A4
SCHEMBL5093999 0.69 TDP2 (0.38) TDP1CDC25BS100A4
SCHEMBL2299734 0.69 CCNA2 (0.40) TDP1CDC25BS100A4
SCHEMBL9175519 0.67 SHMT2 (0.34) L3MBTL1PTPN1
SCHEMBL2822167 0.66 PDCD1 (0.40) TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014179401-A1 2-ARYLNAPHTHYRIDIN-4-ONES AS POTENT ANTITUMOR AGENTS TARGETING TUMORIGENIC CELL LINES KUO SHENG-CHU 2014-11-06 WO disclosed
CN-1252069-C 2-aryl-naphthyridin-4-ones as antitumor agents UNIV NORTH CAROLINA CHAPEL HILL (US) 2006-04-19 CN disclosed
US-6229016-B1 PYRIDOPYRIMIDINE DERIVATIVES AS CHEMICAL INTERMEDIATES; POLYMERIZATION INHIBITION OF TUBULIN THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2001-05-08 US disclosed
US-6229016-B1 PYRIDOPYRIMIDINE DERIVATIVES AS CHEMICAL INTERMEDIATES; POLYMERIZATION INHIBITION OF TUBULIN THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2001-05-08 US disclosed
CN-1259947-A 2-aryl-naphthyridin-4-ones as antitumor agents UNIV NORTH CAROLINA CHAPEL HILL (US) 2000-07-12 CN disclosed
US-6071930-A FOR INHIBITION OF MITOSIS OR TUMOR GROWTH THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2000-06-06 US disclosed
US-6071930-A FOR INHIBITION OF MITOSIS OR TUMOR GROWTH THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2000-06-06 US disclosed
EP-0971921-A1 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS The University of North Carolina at Chapel Hill (US) 2000-01-19 EP disclosed
US-5994367-A PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-11-30 US disclosed
US-5994367-A PREVENT CELL MITOSIS; ANTICARCINOGENIC AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1999-11-30 US disclosed
WO-1998039332-A1 2-ARYL-NAPHTHYRIDIN-4-ONES AS ANTITUMOR AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1998-09-11 WO disclosed