Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL472760 | 0.98 | PTPN1 (0.42) | PTPN1NR1H2NR1H3TDP1L3MBTL1 | |
| SCHEMBL21065455 | 0.98 | PTPN1 (0.42) | PTPN1NR1H2NR1H3TDP1L3MBTL1 | |
| SCHEMBL8780480 | 0.95 | PTPN1 (0.35) | PTPN1NR1H2NR1H3SIGMAR1ALDH1A1 | |
| Phosphoric Acid SCHEMBL27784283 | 0.93 | CETP (0.39) | PTPN1NR1H2NR1H3HPGDMEN1 | |
| SCHEMBL9175519 | 0.89 | SHMT2 (0.34) | PTPN1L3MBTL1ALDH1A1CES1SMN1; SMN2 | |
| SCHEMBL4764684 | 0.82 | SHMT2 (0.39) | TDP1L3MBTL1ALDH1A1CES1SMN1; SMN2 | |
| SCHEMBL9361210 | 0.82 | EPHX2 (0.37) | TDP1L3MBTL1ALDH1A1HPGDMEN1 | |
| SCHEMBL3014252 | 0.79 | ALDH1A1 (0.36) | TDP1L3MBTL1ALDH1A1CES1SMN1; SMN2 | |
| SCHEMBL18172243 | 0.79 | DHODH (0.41) | TDP1L3MBTL1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7913644 | 0.78 | TDP1 (0.39) | PTPN1NR1H2NR1H3TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108610286-B | 2-aryl-4-quinolone derivative and preparation method and application thereof | 绍兴文理学院 | 2021-12-03 | — | — | CN | claimed |
| CN-108610286-A | A kind of 2- aryl-4-quinolones derivative and its preparation method and application | 绍兴文理学院 | 2018-10-02 | — | — | CN | claimed |
| US-9023867-B2 | Hydrophilic derivatives of 2-selenophene-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-05 | — | — | US | claimed |
| US-20130244983-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-SELENOPHENE-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2013-09-19 | — | — | US | claimed |
| US-8440692-B2 | Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2013-05-14 | — | — | US | claimed |
| EP-2096924-B1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | UNIV CHINA MEDICAL (TW) | 2013-02-13 | — | — | EP | claimed |
| US-20100168064-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2010-07-01 | — | — | US | claimed |
| EP-2096924-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | China Medical University (TW) | 2009-09-09 | — | — | EP | claimed |
| WO-2008070176-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2008-06-12 | — | — | WO | claimed |
| WO-1994002145-A2 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | GENELABS TECHNOLOGIES, INC. (US) | 1994-02-03 | — | — | WO | claimed |
| CN-108610286-B | 2-aryl-4-quinolone derivative and preparation method and application thereof | 绍兴文理学院 | 2021-12-03 | — | — | CN | disclosed |
| CN-108610286-B | 2-aryl-4-quinolone derivative and preparation method and application thereof | 绍兴文理学院 | 2021-12-03 | — | — | CN | disclosed |
| CN-108610286-B | 2-aryl-4-quinolone derivative and preparation method and application thereof | 绍兴文理学院 | 2021-12-03 | — | — | CN | disclosed |
| CN-108623563-A | A kind of application of quinolinones compound in drug | 中国海洋大学 | 2018-10-09 | — | — | CN | disclosed |
| CN-108617661-A | A kind of application of alkaloid compound in agricultural drugs | 中国海洋大学 | 2018-10-09 | — | — | CN | disclosed |
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |
| WO-1994002145-A3 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | GENELABS TECH INC (US) | 1994-04-28 | — | — | WO | disclosed |
| WO-1994002145-A2 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | GENELABS TECHNOLOGIES, INC. (US) | 1994-02-03 | — | — | WO | disclosed |
| WO-1994002145-A2 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | GENELABS TECHNOLOGIES, INC. (US) | 1994-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130244983-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-SELENOPHENE-4-QUINOLONES AS ANTICANCER AGENTS | DHX30, SLC20A2, SLC20A1 | PTPN1 743/4885NR1H2 3296/4885NR1H3 3763/4885 |
| US-20100168064-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | DHX30, SLC20A2, DDX20 | PTPN1 1016/4885NR1H2 2643/4885NR1H3 3327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.