Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 9/20 | 0.67 |
| ▸ | TNIK | Q9UKE5 | 9/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.44 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | CHUK | O15111 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7910407 | 0.83 | MAP3K11 (0.47) | MAP3K11TNIKMAP4K1NTRK1 | |
| SCHEMBL724282 | 0.80 | MAP3K11 (1.00) | MAP3K11TNIKMAP3K9IKBKBCHUK | |
| SCHEMBL7907723 | 0.79 | MAP3K11 (0.73) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL7908989 | 0.78 | MAP3K11 (0.63) | MAP3K11TNIKNTRK1CYP3A4LRRK2 | |
| SCHEMBL7907491 | 0.77 | AXL (0.64) | MAP3K11TNIKSGK1NTRK1 | |
| SCHEMBL12066047 | 0.77 | MAP3K11 (0.67) | MAP3K11TNIKMAP4K1MAP3K9IKBKB | |
| SCHEMBL7906295 | 0.77 | MAP4K1 (0.66) | MAP3K11TNIKMAP4K1NTRK1 | |
| SCHEMBL7906551 | 0.77 | KIT (0.57) | MAP3K11TNIKCDK2NTRK1CYP3A4 | |
| SCHEMBL7905041 | 0.77 | NTRK1 (0.63) | MAP3K11TNIKNTRK1CYP3A4 | |
| SCHEMBL7906025 | 0.75 | MAP3K11 (0.69) | MAP3K11TNIKMAP4K1NTRK1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |