Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907478 | 0.91 | NPY1R (0.36) | HRH3NPY1RPRMT5 | |
| SCHEMBL3106981 | 0.87 | HRH3 (0.48) | HRH3KDM1AENPP2OPRM1OPRL1 | |
| SCHEMBL7909106 | 0.84 | MAPT (0.42) | NPY1R | |
| SCHEMBL7908842 | 0.80 | TACR1 (0.40) | HRH3NPY1R | |
| SCHEMBL7912190 | 0.80 | CHRM4 (0.42) | HRH3NPY1R | |
| SCHEMBL13102680 | 0.78 | NPY1R (0.44) | NPY1R | |
| SCHEMBL7909786 | 0.77 | NAMPT (0.41) | HRH3 | |
| SCHEMBL7915500 | 0.75 | ALDH1A1 (0.42) | HRH3 | |
| SCHEMBL7908933 | 0.74 | TSHR (0.41) | — | |
| SCHEMBL13092217 | 0.74 | KMT2A (0.52) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010106081-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-23 | — | — | WO | disclosed |