Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Carnitine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.61 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levocarnitine SCHEMBL4523560 | 0.82 | SLC22A16 (0.83) | SLC22A16CPT2CPT1AMAPTCYP1A2 | |
| Carnitine SCHEMBL3680647 | 0.82 | SLC22A16 (0.83) | SLC22A16CPT2CPT1AMAPTCYP1A2 | |
| SCHEMBL2149905 | 0.81 | ALDH1A1 (0.43) | MAPTALDH1A1KDM4ELMNAHTT | |
| Levocarnitine SCHEMBL5082345 | 0.80 | SLC22A16 (0.80) | SLC22A16CPT2CPT1AMAPTCYP1A2 | |
| Carnitine SCHEMBL5712407 | 0.80 | SLC22A16 (0.80) | SLC22A16CPT2CPT1AMAPTCYP1A2 | |
| Glycinebetaine SCHEMBL6568624 | 0.79 | ALDH1A1 (0.44) | MAPTALDH1A1KDM4ELMNAHTT | |
| Glycerin SCHEMBL3630101 | 0.79 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4ELMNAHTT | |
| Glycerin SCHEMBL28301031 | 0.79 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4ELMNAHTT | |
| Glycerin SCHEMBL2058190 | 0.79 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4ELMNAHTT | |
| Carnitine SCHEMBL28474008 | 0.78 | SLC22A16 (0.56) | SLC22A16CPT2CPT1AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035364-A1 | STABILIZED SOLUTION OF ORTHO-SILICIC ACID, ITS PREPARATION AND USE | CREOGEN D.O.O. (HR) | 2012-03-22 | — | — | WO | disclosed |