Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5670794 | 0.82 | CA12 (0.41) | MMP1MMP2CA12CA1CA2 | |
| SCHEMBL7456860 | 0.81 | PPARD (0.41) | PPARDMMP1MMP2TSHRTP53 | |
| SCHEMBL9449240 | 0.78 | MMP1 (0.39) | MMP1MMP2CA12CA1CA2 | |
| SCHEMBL4995518 | 0.78 | MMP1 (0.40) | PPARDMMP1MMP2CA12CA1 | |
| SCHEMBL17039331 | 0.77 | MMP1 (0.42) | MMP1MMP2CA12CA1CA2 | |
| SCHEMBL9462365 | 0.76 | SIGMAR1 (0.34) | PPARDMMP1MMP2CYP1A2 | |
| SCHEMBL4163826 | 0.75 | PPARD (0.39) | PPARDMMP1MMP2CA12CA1 | |
| SCHEMBL17039329 | 0.74 | MMP1 (0.40) | PPARDMMP1MMP2TSHRTP53 | |
| SCHEMBL778015 | 0.73 | SRC (0.41) | MMP1MMP2CA12CA1CA2 | |
| SCHEMBL18311508 | 0.73 | MMP1 (0.39) | MMP1MMP2TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |
| WO-1998050030-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |