Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10440229 | 0.88 | CYP1A2 (0.41) | ADORA2ACD274ABL1CTSA | |
| SCHEMBL8070542 | 0.80 | MET (0.45) | ABL1 | |
| SCHEMBL3466353 | 0.79 | MAPK1 (0.42) | KMT2AABL1 | |
| SCHEMBL3466339 | 0.78 | HCRTR1 (0.39) | CTSA | |
| SCHEMBL3788516 | 0.77 | CYP1A2 (0.40) | ADORA2ACD274KMT2AABL1 | |
| SCHEMBL7913183 | 0.77 | MAPK1 (0.41) | ABL1 | |
| SCHEMBL7917992 | 0.76 | ADORA2A (0.38) | ADORA2AFFAR1KMT2AKITCTSA | |
| SCHEMBL10442060 | 0.73 | SMN1; SMN2 (0.40) | FFAR1MTNR1AMTNR1BKITCTSA | |
| SCHEMBL7916577 | 0.71 | PDE4D (0.41) | CTSA | |
| Hydrochloric Acid SCHEMBL3790284 | 0.70 | PDE4D (0.41) | CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |