Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.42 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3785940 | 0.87 | MET (0.43) | METMAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL7913183 | 0.84 | MAPK1 (0.41) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL3466353 | 0.80 | MAPK1 (0.42) | METMAPK1PIK3CAMAPK8MAPK9 | |
| SCHEMBL7915416 | 0.80 | ADORA2A (0.39) | ABL1 | |
| SCHEMBL7913034 | 0.75 | MAPK1 (0.42) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL8031130 | 0.74 | MAPK1 (0.42) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL8055903 | 0.72 | MAPK1 (0.44) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL13578431 | 0.72 | MAPK1 (0.40) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL3792884 | 0.72 | MAPK1 (0.43) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL8069438 | 0.70 | CLK4 (0.44) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |