Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7917158 | 0.95 | MTNR1A (0.50) | MTNR1AMTNR1BMMESYKCA1 | |
| SCHEMBL7919569 | 0.83 | MTNR1A (0.49) | MTNR1AMTNR1BMMECA1CA2 | |
| SCHEMBL7919881 | 0.82 | MTNR1A (0.51) | MTNR1AMTNR1BMMEMAOAMAOB | |
| SCHEMBL7921878 | 0.78 | EPHX1 (0.44) | EPHX1EPHX2MITFKMT2A | |
| SCHEMBL7922905 | 0.74 | MME (0.48) | MMEGRIN2BATM | |
| SCHEMBL7918857 | 0.73 | ATM (0.59) | EPHX1MITFKMT2AATM | |
| SCHEMBL7922883 | 0.72 | KMT2A (0.34) | MITFKMT2AATM | |
| SCHEMBL7919878 | 0.68 | EPHX1 (0.50) | EPHX1EPHX2KMT2A | |
| SCHEMBL7910450 | 0.68 | ATM (0.61) | EPHX1KMT2AATM | |
| SCHEMBL9851515 | 0.68 | MTNR1A (0.73) | MTNR1AMTNR1BCA1CA2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054968-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-20 | — | — | WO | disclosed |