Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919569 | 0.92 | MTNR1A (0.49) | MMESLC6A2SLC6A4SLC6A3SMYD3 | |
| SCHEMBL7919878 | 0.86 | EPHX1 (0.50) | SLC6A2SLC6A4SLC6A3SMYD3SSTR4 | |
| SCHEMBL7910472 | 0.81 | SSTR4 (0.41) | SLC6A2SLC6A4SLC6A3SMYD3ATM | |
| SCHEMBL7919565 | 0.80 | EPHX2 (0.50) | SLC6A2SLC6A4SLC6A3SMYD3KDM4E | |
| SCHEMBL7921872 | 0.80 | EPHX2 (0.50) | SLC6A2SLC6A4SLC6A3SMYD3KDM4E | |
| SCHEMBL4375995 | 0.78 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3SMYD3ATM | |
| SCHEMBL2172656 | 0.77 | ATM (0.57) | SLC6A2SLC6A4SLC6A3ATMCYP2D6 | |
| SCHEMBL7917158 | 0.76 | MTNR1A (0.50) | MMEGRM7ATMGRIN2B | |
| SCHEMBL1919144 | 0.76 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3SMYD3ATM | |
| SCHEMBL4372327 | 0.75 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3SMYD3ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054968-A1 | QUINAZOLINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-20 | — | — | WO | disclosed |