Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244902 | 0.82 | LTA4H (0.81) | LTA4HHRH3KDM4EALDH1A1LMNA | |
| SCHEMBL14970473 | 0.82 | LTA4H (0.81) | LTA4HHRH3KDM4EALDH1A1LMNA | |
| SCHEMBL7999188 | 0.82 | HRH3 (0.75) | LTA4HHRH3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL14969107 | 0.81 | LTA4H (0.79) | LTA4HHRH3KDM4EALDH1A1LMNA | |
| SCHEMBL8107620 | 0.80 | HRH3 (0.75) | LTA4HHRH3KDM4EALDH1A1 | |
| SCHEMBL16024760 | 0.80 | SLC6A3 (0.66) | LTA4HKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL13493035 | 0.80 | KDM4E (0.74) | LTA4HHRH3KDM4EALDH1A1 | |
| SCHEMBL19043551 | 0.79 | HRH3 (0.69) | LTA4HHRH3LMNAHTTKMT2A | |
| SCHEMBL4177277 | 0.79 | LTA4H (0.67) | LTA4HHRH3KDM4EALDH1A1LMNA | |
| SCHEMBL22813669 | 0.79 | HRH3 (0.64) | LTA4HHRH3CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2009117150-A2 | METHOD OF TREATING LUPUS WITH CERAMIDE DERIVATIVES | GENZYME CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |