Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | TPO | P07202 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1961032 | 1.00 | MPO (0.55) | MPOTPOALDH1A1HSD17B10GAA | |
| SCHEMBL1962177 | 0.84 | MPO (0.59) | MPOTPOALDH1A1HSD17B10GAA | |
| SCHEMBL3256669 | 0.84 | MPO (0.59) | MPOTPOALDH1A1HSD17B10GAA | |
| SCHEMBL1958096 | 0.81 | ALDH1A1 (0.40) | MPOTPOALDH1A1POLBTSHR | |
| SCHEMBL2484816 | 0.81 | ALDH1A1 (0.35) | MPOTPOALDH1A1HSD17B10MAPT | |
| SCHEMBL1959309 | 0.74 | MPO (0.56) | MPOTPOALDH1A1HSD17B10GAA | |
| SCHEMBL1960671 | 0.71 | MPO (1.00) | MPOTPOALDH1A1HSD17B10GAA | |
| SCHEMBL2280952 | 0.71 | MPO (1.00) | MPOTPOALDH1A1HSD17B10GAA | |
| SCHEMBL2288062 | 0.71 | MPO (1.00) | MPOTPOALDH1A1HSD17B10GAA | |
| SCHEMBL1962737 | 0.69 | SMN1; SMN2 (0.41) | MPOALDH1A1GAAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068171-A1 | A PROCESS FOR THE PREPARATION OF 3- [ (2R) TETRAHYDROFURAN-2- YLMETHYL] -2-THIOXO-L, 2, 3, 7-TETRAHYDRO-6H-PURIN-6-ONE | ASTRAZENECA AB (SE) | 2010-06-17 | — | — | WO | disclosed |