Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7908156 | 0.80 | JAK2 (0.43) | JAK2JAK1KMT2AGRIN2BACHE | |
| Oxalic Acid SCHEMBL7908151 | 0.80 | JAK2 (0.43) | JAK2JAK1KMT2AGRIN2BACHE | |
| SCHEMBL7908300 | 0.80 | GRIN2B (0.44) | JAK2JAK1GRIN2BAGTR2OPRM1 | |
| SCHEMBL7908299 | 0.80 | GRIN2B (0.44) | JAK2JAK1GRIN2BAGTR2OPRM1 | |
| Oxalic Acid SCHEMBL7917823 | 0.77 | ALOX5 (0.44) | JAK2JAK1KMT2AOPRM1SIGMAR1 | |
| Oxalic Acid SCHEMBL7917829 | 0.77 | ALOX5 (0.44) | JAK2JAK1KMT2AOPRM1SIGMAR1 | |
| SCHEMBL7908155 | 0.76 | JAK2 (0.43) | JAK2JAK1KMT2AGRIN2BACHE | |
| SCHEMBL7908154 | 0.76 | JAK2 (0.43) | JAK2JAK1KMT2AGRIN2BACHE | |
| SCHEMBL7918443 | 0.74 | ALOX5 (0.46) | JAK2JAK1KMT2AOPRM1SIGMAR1 | |
| SCHEMBL7918436 | 0.74 | ALOX5 (0.46) | JAK2JAK1KMT2AOPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211219-B1 | DRUGS, ANALGESICS AND AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2001-04-03 | — | — | US | disclosed |