Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7908156 | 1.00 | JAK2 (0.43) | JAK2JAK1GRIN2BKMT2AHPGD | |
| SCHEMBL7908155 | 0.83 | JAK2 (0.43) | JAK2JAK1GRIN2BKMT2AHPGD | |
| SCHEMBL7908154 | 0.83 | JAK2 (0.43) | JAK2JAK1GRIN2BKMT2AHPGD | |
| SCHEMBL7921383 | 0.82 | YTHDC1 (0.45) | GRIN2BKMT2ASLC18A3RAB9A | |
| Oxalic Acid SCHEMBL7917823 | 0.81 | ALOX5 (0.44) | JAK2JAK1KMT2ANPC1OPRM1 | |
| Oxalic Acid SCHEMBL7917829 | 0.81 | ALOX5 (0.44) | JAK2JAK1KMT2ANPC1OPRM1 | |
| Oxalic Acid SCHEMBL7916381 | 0.80 | JAK2 (0.41) | JAK2JAK1GRIN2BKMT2ASLC18A3 | |
| SCHEMBL7908300 | 0.79 | GRIN2B (0.44) | JAK2JAK1GRIN2BSLC18A3AGTR2 | |
| SCHEMBL7908299 | 0.79 | GRIN2B (0.44) | JAK2JAK1GRIN2BSLC18A3AGTR2 | |
| SCHEMBL7918443 | 0.78 | ALOX5 (0.46) | JAK2JAK1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211219-B1 | DRUGS, ANALGESICS AND AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2001-04-03 | — | — | US | disclosed |