Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7917823 | 1.00 | ALOX5 (0.44) | ALOX5L3MBTL1JAK2JAK1LTA4H | |
| SCHEMBL7918443 | 0.98 | ALOX5 (0.46) | ALOX5L3MBTL1JAK2JAK1LTA4H | |
| SCHEMBL7918436 | 0.98 | ALOX5 (0.46) | ALOX5L3MBTL1JAK2JAK1LTA4H | |
| SCHEMBL7917801 | 0.89 | ALOX5 (0.47) | ALOX5L3MBTL1LTA4HALDH1A1TDP1 | |
| Oxalic Acid SCHEMBL7908156 | 0.81 | JAK2 (0.43) | JAK2JAK1KMT2AOPRM1NPC1 | |
| Oxalic Acid SCHEMBL7908151 | 0.81 | JAK2 (0.43) | JAK2JAK1KMT2AOPRM1NPC1 | |
| SCHEMBL7908154 | 0.80 | JAK2 (0.43) | L3MBTL1JAK2JAK1KMT2ANPC1 | |
| SCHEMBL7908155 | 0.80 | JAK2 (0.43) | L3MBTL1JAK2JAK1KMT2ANPC1 | |
| Oxalic Acid SCHEMBL7916381 | 0.77 | JAK2 (0.41) | L3MBTL1JAK2JAK1ALDH1A1KMT2A | |
| SCHEMBL3901891 | 0.76 | ALDH1A1 (0.46) | ALOX5L3MBTL1ALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211219-B1 | DRUGS, ANALGESICS AND AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2001-04-03 | — | — | US | disclosed |