SCHEMBL7917441

SCHEMBL7917441

COC(C)OC1CCC(C(=O)O)CC1.FC(C(F)(F)F)C(F)(F)Oc1ccc(-c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
TSHR P16473 1/20 0.44
HSD17B10 Q99714 1/20 0.44
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
MMP12 P39900 4/20 0.35
VCP P55072 1/20 0.35
ACSL1 P33121 3/20 0.34
CYP1A2 P05177 1/20 0.33
GAA P10253 1/20 0.33
CYP2C9 P11712 1/20 0.33
PKM P14618 1/20 0.33
CYP2C19 P33261 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
HPGD P15428 1/20 0.33
KMT2A Q03164 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
EPHX2 P34913 2/20 0.32
GPR88 Q9GZN0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7913618 0.90 ALDH1A1 (0.42) ALDH1A1TSHRHSD17B10NPC1RAB9A
SCHEMBL7911766 0.84 ALDH1A1 (0.44) ALDH1A1TSHRHSD17B10NPC1RAB9A
SCHEMBL7913642 0.83 ALDH1A1 (0.44) ALDH1A1TSHRHSD17B10KDM4EMEN1
SCHEMBL7917443 0.83 ALDH1A1 (0.43) ALDH1A1TSHRHSD17B10NPC1RAB9A
SCHEMBL7913553 0.81 ALDH1A1 (0.43) ALDH1A1TSHRHSD17B10NPC1RAB9A
SCHEMBL7913576 0.81 ALDH1A1 (0.38) ALDH1A1TSHRHSD17B10KDM4EMEN1
SCHEMBL7913621 0.80 ALDH1A1 (0.42) ALDH1A1TSHRHSD17B10NPC1RAB9A
SCHEMBL7914029 0.80 ALDH1A1 (0.44) ALDH1A1TSHRHSD17B10NPC1RAB9A
SCHEMBL7988352 0.73 ALDH1A1 (0.60) ALDH1A1TSHRHSD17B10CYP1A2GAA
SCHEMBL7913822 0.73 ALDH1A1 (0.43) ALDH1A1TSHRHSD17B10HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640578-B2 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition CHISSO CORP (JP) 2001-06-27 EP disclosed
EP-0640578-B1 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition CHISSO CORP (JP) 1997-11-05 EP disclosed
EP-0640578-A1 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition Chisso Corporation (JP) 1995-03-01 EP disclosed