Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515851 | 0.94 | IDO1 (0.47) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL3403146 | 0.88 | CYP11B1 (0.41) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL7861158 | 0.88 | HDAC4 (0.42) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL3905843 | 0.86 | CES2 (0.44) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL2562362 | 0.83 | HDAC4 (0.47) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL7818627 | 0.82 | AKR1C3 (0.44) | CES2CES1 | |
| SCHEMBL7862422 | 0.82 | HDAC4 (0.39) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL15545304 | 0.81 | HDAC4 (0.41) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL15528140 | 0.81 | HDAC4 (0.41) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL7828556 | 0.80 | MEN1 (0.34) | HDAC4HDAC7HDAC5CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174898-B1 | TREATING FILARIAE IN LYMPHATIC SYSTEM BY ADMINISTERING N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS IN WHICH A SUBSTITUTED ALKYL CHAIN FORMS PART OF N-SUBSTITUENT AND SALTS | NOVO NORDISK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| EP-0374801-B1 | Novel N-sustituted azaheterocyclic carboxylic acids | NOVO NORDISK AS (DK) | 1997-03-19 | — | — | EP | disclosed |
| EP-0430771-B1 | Isoindolone derivatives, their preparation and their use as intermediates for the preparation of substance P antagonists | RHONE POULENC SANTE (FR) | 1994-07-20 | — | — | EP | disclosed |
| EP-0429366-B1 | Isoindolone derivatives, their preparation and pharmaceutical compositions containing them | RHONE POULENC SANTE (FR) | 1994-03-16 | — | — | EP | disclosed |
| US-5214057-A | Used as analgesic, anxiolytic, antidepressant, hypnotic and for treating epilepsy and muscular disorder | NOVO NORDISK A/S (DK) | 1993-05-25 | — | — | US | disclosed |
| US-5112988-A | ISOINDOLONE DERIVATIVES | RHONE-POULENC SANTE (FR) | 1992-05-12 | — | — | US | disclosed |
| US-5102667-A | Antiallergens, antiinflammatory agents, nervous system disorders, immunology, psychological disorders | RHONE-POULENC SANTE (FR) | 1992-04-07 | — | — | US | disclosed |
| US-5071859-A | Analgesic, antianxiolytic, antiepileptic, antidepressant; gammaa-aminobutyric acid inhibitor | NOVO NORDISK A/S, A CORP. OF DENMARK (DK) | 1991-12-10 | — | — | US | disclosed |
| EP-0430771-A1 | Isoindolone derivatives, their preparation and their use as intermediates for the preparation of substance P antagonists | RHONE-POULENC SANTE (FR) | 1991-06-05 | — | — | EP | disclosed |
| EP-0429366-A1 | Isoindolone derivatives, their preparation and pharmaceutical compositions containing them | RHONE-POULENC SANTE (FR) | 1991-05-29 | — | — | EP | disclosed |
| EP-0374801-A2 | Novel N-sustituted azaheterocyclic carboxylic acids | NOVO NORDISK A/S (DK) | 1990-06-27 | — | — | EP | disclosed |