Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862422 | 0.80 | HDAC4 (0.39) | MEN1KMT2AHDAC4HDAC7HDAC5 | |
| SCHEMBL7917545 | 0.80 | HDAC4 (0.47) | HDAC4HDAC7HDAC5RAB9ACES2 | |
| SCHEMBL7029532 | 0.75 | NPSR1 (0.34) | MEN1KMT2AMAPT | |
| SCHEMBL1515851 | 0.75 | IDO1 (0.47) | MEN1KMT2AHDAC4HDAC7HDAC5 | |
| SCHEMBL7861158 | 0.73 | HDAC4 (0.42) | HDAC4HDAC7HDAC5MAPTCES2 | |
| SCHEMBL7818627 | 0.71 | AKR1C3 (0.44) | CES2CES1 | |
| SCHEMBL3403146 | 0.70 | CYP11B1 (0.41) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL7819110 | 0.70 | SLC6A2 (0.34) | MEN1KMT2AMAPTRAB9AIDO1 | |
| SCHEMBL8489218 | 0.69 | ALDH1A1 (0.42) | MEN1KMT2AMAPTRAB9ATAS1R3 | |
| SCHEMBL3905843 | 0.69 | CES2 (0.44) | HDAC4HDAC7HDAC5CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000061571-A1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORPORATION (KR) | 2000-10-19 | — | — | WO | disclosed |