Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19043506 | 1.00 | HRH3 (0.60) | HRH3KCNH2GRIN2BLTA4H | |
| SCHEMBL7922904 | 0.88 | LTA4H (0.58) | HRH3GRIN2BLTA4H | |
| SCHEMBL19043795 | 0.86 | SPHK1 (0.47) | HRH3 | |
| SCHEMBL7927897 | 0.82 | HRH3 (0.76) | HRH3LTA4H | |
| SCHEMBL23963302 | 0.82 | LTA4H (0.57) | HRH3KCNH2LTA4H | |
| SCHEMBL28386934 | 0.82 | LTA4H (0.57) | HRH3KCNH2LTA4H | |
| SCHEMBL23963274 | 0.82 | LTA4H (0.57) | HRH3KCNH2LTA4H | |
| SCHEMBL19042296 | 0.81 | HRH3 (0.74) | HRH3LTA4H | |
| SCHEMBL19043574 | 0.81 | HRH3 (0.79) | HRH3 | |
| SCHEMBL20382412 | 0.78 | HRH3 (0.49) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |