Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.56 |
| ▸ | HRH2 | P25021 | 4/20 | 0.56 |
| ▸ | HRH1 | P35367 | 4/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19043506 | 0.88 | HRH3 (0.60) | LTA4HHRH3GRIN2B | |
| SCHEMBL7917842 | 0.88 | HRH3 (0.60) | LTA4HHRH3GRIN2B | |
| SCHEMBL13493053 | 0.87 | RAB9A (0.62) | LTA4HHRH3HRH2HRH1ACHE | |
| SCHEMBL7994498 | 0.81 | HRH3 (0.51) | LTA4HHRH3HRH2HRH1ACHE | |
| SCHEMBL6796838 | 0.81 | SIGMAR1 (0.57) | LTA4HHRH3HRH2HRH1GRIN2B | |
| SCHEMBL6796835 | 0.81 | SIGMAR1 (0.57) | LTA4HHRH3HRH2HRH1GRIN2B | |
| SCHEMBL7927897 | 0.80 | HRH3 (0.76) | LTA4HHRH3ACHEMEN1KMT2A | |
| SCHEMBL19042296 | 0.79 | HRH3 (0.74) | LTA4HHRH3ACHEMEN1KMT2A | |
| SCHEMBL19043574 | 0.79 | HRH3 (0.79) | HRH3ACHEMEN1KMT2A | |
| SCHEMBL7998015 | 0.78 | LTA4H (0.48) | LTA4HHRH3HRH2HRH1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010014554-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |