Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | RAD52 | P43351 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19042296 | 0.99 | HRH3 (0.74) | HRH3MEN1LMNAHTTKMT2A | |
| SCHEMBL19043574 | 0.99 | HRH3 (0.79) | HRH3MEN1LMNAHTTKMT2A | |
| SCHEMBL31060371 | 0.87 | HRH3 (1.00) | HRH3ACHERAD52 | |
| SCHEMBL8114961 | 0.85 | HRH3 (0.73) | HRH3MEN1LMNAHTTKMT2A | |
| SCHEMBL19043080 | 0.85 | HRH3 (0.77) | HRH3ACHERAD52LTA4H | |
| SCHEMBL19042306 | 0.84 | SIGMAR1 (0.64) | HRH3LTA4HL3MBTL1 | |
| SCHEMBL13492993 | 0.84 | LTA4H (0.76) | HRH3LTA4H | |
| SCHEMBL7999523 | 0.84 | HRH3 (0.78) | HRH3ACHERAD52LTA4H | |
| SCHEMBL7999188 | 0.84 | HRH3 (0.75) | HRH3LTA4H | |
| SCHEMBL8107620 | 0.84 | HRH3 (0.75) | HRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594563-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-3078373-A1 | 2-ACYLAMINOPROPANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITOR | Genzyme Corporation (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |