Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920547 | 1.00 | MEN1 (0.38) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL12203923 | 0.91 | MEN1 (0.36) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL7917374 | 0.91 | GHSR (0.42) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL7922109 | 0.84 | GHSR (0.36) | GHSRDPP8DPP9EPHX2MME | |
| SCHEMBL7917735 | 0.83 | GHSR (0.38) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL7916929 | 0.80 | GHSR (0.41) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL7921532 | 0.80 | GHSR (0.41) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL7909436 | 0.79 | RAB9A (0.38) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL15353791 | 0.79 | NPC1 (0.38) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL7918729 | 0.78 | NPC1 (0.37) | MEN1NPC1HTTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042473-A1 | BIARYL SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |