Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.61 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 4/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918881 | 1.00 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA7CHRNA5CYP2D6 | |
| SCHEMBL7271039 | 0.97 | CYP2D6 (0.60) | CHRNB2CHRNA4CHRNA7CHRNA5CYP2D6 | |
| SCHEMBL7269469 | 0.97 | CYP2D6 (0.60) | CHRNB2CHRNA4CHRNA7CHRNA5CYP2D6 | |
| SCHEMBL7269463 | 0.97 | CYP2D6 (0.60) | CHRNB2CHRNA4CHRNA7CHRNA5CYP2D6 | |
| SCHEMBL7277894 | 0.96 | CYP2D6 (0.62) | CHRNB2CHRNA4CHRNA7CHRNA5CYP2D6 | |
| SCHEMBL7299257 | 0.90 | CYP2D6 (0.64) | CHRNB2CHRNA4CHRNA7CYP2D6ALDH1A1 | |
| SCHEMBL7280163 | 0.88 | CYP2D6 (0.64) | CHRNB2CHRNA4CHRNA7CYP2D6ALDH1A1 | |
| SCHEMBL7269282 | 0.86 | RAB9A (0.57) | CHRNB2CHRNA4CHRNA7CYP2D6ALDH1A1 | |
| SCHEMBL7270870 | 0.86 | RAB9A (0.62) | CHRNB2CHRNA4CHRNA7CYP2D6ALDH1A1 | |
| SCHEMBL7276029 | 0.84 | RAB9A (0.56) | CHRNB2CHRNA4CHRNA7CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221878-B1 | ANTAGONISTS OF 5-HYDROXYTRYPTAMINE (5-HT) AT 5-HT3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2001-04-24 | — | — | US | disclosed |
| US-5420139-A | Administering 4-amino-N-1-azabicyclo(2.2.2)oct-3-yl-5-chloro-2-methoxybenzamide | GLAXO GROUP LIMITED (GB) | 1995-05-30 | — | — | US | disclosed |
| US-5330982-A | Promote gastric emptying | GLAXO GROUP LIMITED (GB) | 1994-07-19 | — | — | US | disclosed |
| US-5298510-A | Relief of side effects resulting from drug withdrawal, treatment of addiction, indole derivatives | GLAXO GROUP LIMITED (GB) | 1994-03-29 | — | — | US | disclosed |
| US-5246941-A | Serotonin antagonist | GLAXO GROUP LIMITED (GB) | 1993-09-21 | — | — | US | disclosed |
| US-5244909-A | Methods for the treatment of cognitive disorders | GLAXO GROUP LIMITED (GB) | 1993-09-14 | — | — | US | disclosed |
| US-5200414-A | Adiminstering endo-N-(8-methyl-8-azabicyclooct-3-yl)-2,3-dihydro-3,3-dimethyl-indole-1 -carboxamide as a 5-hydroxytrypt-amine antagonist | GLAXO GROUP LIMITED (GB) | 1993-04-06 | — | — | US | disclosed |
| US-5190954-A | 5-Hydroxytryptamine Antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-02 | — | — | US | disclosed |
| US-5071854-A | Hydroxytryptamine antagonists | GLAXO GROUP LIMITED (GB) | 1991-12-10 | — | — | US | disclosed |
| US-5001133-A | Benzoic acid derivatives | SANDOZ LTD. (CH) | 1991-03-19 | — | — | US | disclosed |
| US-4985437-A | 5-HYDROXYTRYPTAMINE ANTAGONISTS, COGNITION ACTIVATORS | GLAXO GROUP LIMITED (GB) | 1991-01-15 | — | — | US | disclosed |
| US-4973594-A | TREATMENT OF DEPRESSION | GLAXO GROUP LIMITED (GB) | 1990-11-27 | — | — | US | disclosed |
| US-4948803-A | USING AZABICYCLOINDAZOLE-3-CARBOXAMIDES | GLAXO GROUP LIMITED (GB) | 1990-08-14 | — | — | US | disclosed |
| WO-1988003801-A1 | MEDICAMENTS FOR TREATMENT OR PREVENTION OF WITHDRAWAL SYNDROME | GLAXO GROUP LIMITED (GB) | 1988-06-02 | — | — | WO | disclosed |