Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.37 |
| ▸ | TK1 | P04183 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.36 |
| ▸ | TK2 | O00142 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NT5M | Q9NPB1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8069871 | 0.90 | TYMP (0.37) | TYMPTK1ALDH1A1LMNAALB | |
| SCHEMBL8772083 | 0.87 | TOP2A (0.35) | TYMPTK1RNASE1TK2HPGD | |
| SCHEMBL701863 | 0.74 | SLC28A1 (0.41) | — | |
| SCHEMBL10644833 | 0.74 | TOP2A (0.41) | TYMPTK1RNASE1TK2 | |
| SCHEMBL10643570 | 0.74 | TK2 (0.45) | TYMPTK1ALDH1A1RNASE1TK2 | |
| SCHEMBL10647357 | 0.74 | TK2 (0.45) | TYMPTK1ALDH1A1RNASE1TK2 | |
| SCHEMBL10646821 | 0.74 | TOP2A (0.41) | TYMPTK1RNASE1TK2 | |
| SCHEMBL5668666 | 0.73 | P2RY2 (0.44) | — | |
| SCHEMBL18652716 | 0.73 | TK1 (0.38) | TYMPTK1RNASE1TK2NT5M | |
| SCHEMBL15087050 | 0.73 | TK1 (0.38) | TYMPTK1RNASE1TK2NT5M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214551-B1 | CONTACTING TEST SOLUTION CONTAINING NUCLEIC ACID WITH COMPOUND CONTAINING NUCLEOSIDE SEQUENCE WHEREIN NUCLEOSIDES ARE COVALENTLY BOUND THROUGH LINKING GROUP HAVING ADJACENT NITROGEN ATOMS FOR ASSAYING SEQUENCE-SPECIFIC NUCLEIC ACID | ISIS PHARMACEUTICALS, INC. | 2001-04-10 | — | — | US | disclosed |
| US-5965721-A | WITH IMPROVED NUCLEASE RESISTANCE AND IMPROVED CELLULAR UPTAKE; FOR ANTISENSE AGENTS AND REGULATION OF RNA EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5610289-A | Backbone modified oligonucleotide analogues | ISIS PHARMACEUTICALS, INC. (US) | 1997-03-11 | — | — | US | disclosed |
| US-5489677-A | NUCLEASE RESISTANT OLIGONUCLEOTIDE ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 1996-02-06 | — | — | US | disclosed |
| EP-0586570-A4 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGUES | ISIS PHARMACEUTICALS INC (US) | 1996-01-24 | — | — | EP | disclosed |
| US-5386023-A | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling | ISIS PHARMACEUTICALS (US) | 1995-01-31 | — | — | US | disclosed |
| WO-1994022893-A1 | OLIGONUCLEOSIDE LINKAGES CONTAINING ADJACENT NITROGEN ATOMS | ISIS PHARMACEUTICALS, INC. (US) | 1994-10-13 | — | — | WO | disclosed |
| WO-1994022883-A1 | BACKBONE MODIFIED OLIGONUCLEOTIDES AND THEIR PREPARATION | ISIS PHARMACEUTICALS, INC. (US) | 1994-10-13 | — | — | WO | disclosed |
| EP-0586570-A1 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGUES | ISIS PHARMACEUTICALS, INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992020822-A1 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGUES | ISIS PHARMACEUTICALS, INC. (US) | 1992-11-26 | — | — | WO | disclosed |