SCHEMBL7919720

SCHEMBL7919720

COC(=O)C(c1ccc(Cl)cc1)c1c(Cl)cc(NN)cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.44
HDAC4 P56524 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
FFAR2 O15552 1/20 0.39
SLC6A3 Q01959 3/20 0.39
KMT2A Q03164 2/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
MEN1 O00255 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CNR1 P21554 1/20 0.37
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18547195 0.81 HDAC4 (0.57) L3MBTL1HDAC4HDAC7HDAC5FFAR2
SCHEMBL1978245 0.81 HDAC4 (0.57) L3MBTL1HDAC4HDAC7HDAC5FFAR2
SCHEMBL7919691 0.76 TMPRSS4 (0.38) L3MBTL1SLC6A3CNR1
SCHEMBL27965750 0.74 L3MBTL1 (0.50) L3MBTL1HDAC4HDAC7HDAC5FFAR2
SCHEMBL7910057 0.72 MDM2 (0.36) L3MBTL1SLC6A3SLC6A2SLC6A4
SCHEMBL7922537 0.71 MAPT (0.39) L3MBTL1SLC6A3KMT2ANPC1RAB9A
SCHEMBL21787635 0.71 L3MBTL1 (0.49) L3MBTL1HDAC4HDAC7HDAC5FFAR2
SCHEMBL949748 0.71 L3MBTL1 (0.49) L3MBTL1HDAC4HDAC7HDAC5FFAR2
SCHEMBL11803550 0.70 EDNRA (0.62) L3MBTL1KMT2AMEN1KDM4E
SCHEMBL4064082 0.70 ALDH1A1 (0.56) L3MBTL1HDAC4HDAC7HDAC5FFAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211178-B1 ANTIPROTOZOA AGENTS FOR COCCIDIOIDES; CYCLIZATION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US disclosed
US-5994355-A ANTIPROTOZOA AGENTS, PARASITICIDE; VETERINARY MEDICINE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-11-30 US disclosed
EP-0648760-B1 Triazine derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-01-27 EP disclosed
EP-0648760-A2 Triazine derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-04-19 EP disclosed