Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9806651 | 0.73 | TDP1 (0.47) | LOXL2ALDH1A1TSHRCYP3A4KDM4E | |
| SCHEMBL617628 | 0.71 | LMNA (0.47) | MAPTLMNALOXL2CYP2D6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3126609 | 0.71 | CYP3A4 (0.45) | ALDH1A1CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL197143 | 0.71 | CYP3A4 (0.45) | ALDH1A1CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL17008412 | 0.71 | CYP3A4 (0.45) | ALDH1A1CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL11017606 | 0.71 | CYP3A4 (0.45) | ALDH1A1CYP3A4KDM4E | |
| SCHEMBL7913161 | 0.69 | CYP2A6 (0.44) | MAPTLMNACYP2D6ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9806640 | 0.67 | CYP3A4 (0.41) | TSHRCYP3A4KDM4E | |
| SCHEMBL723376 | 0.67 | CYP3A4 (0.47) | LOXL2ALDH1A1TSHRCYP3A4KDM4E | |
| SCHEMBL8850573 | 0.67 | CYP3A4 (0.47) | LOXL2ALDH1A1TSHRCYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218378-B1 | FOR THERAPY OR INHIBITION OF OVARIAN TUMORS, CERVICAL TUMORS, LUNG CANCER AND MELANOMA | GRIFFITH UNIVERSITY (AU) | 2001-04-17 | — | — | US | disclosed |
| US-6159957-A | Method of treatment or inhibition of tumors using pyridyl-substituted metal-diphosphine complexes | GRIFFITH UNIVERSITY (AU) | 2000-12-12 | — | — | US | disclosed |
| EP-0198696-B1 | PHOSPHINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4902675-A | ANTITUMOR AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1990-02-20 | — | — | US | disclosed |
| US-4755611-A | Certain bio-(bi-2-thienyl or 2-furyl phosphino) lower alkanes having anti-tumor properties | SMITHKLINE BECKMAN CORPORATION (US) | 1988-07-05 | — | — | US | disclosed |
| US-4716230-A | Certain bis(di-2 or 4-pyridyl-phosphino) alkanes #10 having anti-tumor properties | SMITHKLINE BECKMAN CORPORATION (US) | 1987-12-29 | — | — | US | disclosed |
| EP-0198696-A2 | Phosphine compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1986-10-22 | — | — | EP | disclosed |