Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 3/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10439124 | 0.83 | NPC1 (0.55) | THRBKMT2ANPBWR1MCHR1HSP90AA1 | |
| SCHEMBL7919792 | 0.80 | MEN1 (0.56) | THRBMEN1NR1I2KMT2ATHRA | |
| SCHEMBL9166052 | 0.75 | MEN1 (0.54) | THRBMEN1NR1I2KMT2ATHRA | |
| SCHEMBL11460749 | 0.74 | MEN1 (0.51) | THRBMEN1NR1I2KMT2ATHRA | |
| SCHEMBL3348736 | 0.74 | P2RX7 (0.48) | THRBMEN1NR1I2KMT2ATHRA | |
| SCHEMBL30504581 | 0.74 | THRB (0.58) | THRBTHRAP2RX7 | |
| SCHEMBL30504582 | 0.74 | THRB (0.58) | THRBTHRAP2RX7 | |
| SCHEMBL8961567 | 0.74 | THRB (0.58) | THRBTHRAP2RX7 | |
| SCHEMBL6242523 | 0.74 | CNOT7 (0.51) | THRBMEN1NR1I2KMT2AP2RX7 | |
| SCHEMBL3582300 | 0.73 | TSHR (0.42) | THRBMEN1NR1I2KMT2AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024260309-A1 | THR-β RECEPTOR AGONIST, PREPARATION METHOD THEREFOR, AND USE METHOD THEREFOR | 西威埃医药技术（上海）有限公司 | 2024-12-26 | — | — | WO | disclosed |
| EP-3965884-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2022-03-16 | — | — | EP | disclosed |