Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.50 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867557 | 0.86 | KCNK3 (0.50) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5868042 | 0.83 | CCNA2 (0.63) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5867793 | 0.80 | CCNA2 (0.52) | RAB9AKMT2ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL5867450 | 0.80 | CDK2 (0.71) | NPC1RAB9AKMT2ATP53MITF | |
| SCHEMBL5867513 | 0.79 | GLS (0.48) | NPC1RAB9AKMT2AHSD17B10MEN1 | |
| SCHEMBL5867879 | 0.78 | MEN1 (0.54) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5867902 | 0.76 | MAPT (0.49) | KMT2AKDM4ELMNAHSD17B10TP53 | |
| SCHEMBL5867393 | 0.76 | CDK2 (0.60) | KMT2ASMN1; SMN2KDM4EHTTGAA | |
| SCHEMBL5867887 | 0.75 | CDK2 (0.51) | NPC1RAB9ASMN1; SMN2KDM4EHTT | |
| SCHEMBL5867690 | 0.75 | CRACR2A (0.52) | NPC1RAB9AKMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218418-B1 | THERAPY OF CELL PROLIFERATIVE DISORDERS ASSOCIATED WITH AN ALTERED CELL DEPENDENT KINASE ACTIVITY BY ADMINISTERING AMINO PYRAZOLE DERIVATIVE TO MAMMAL | PHARMACIA & UPJOHN S.P.A (IT) | 2001-04-17 | — | — | US | disclosed |