Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867393 | 0.84 | CDK2 (0.60) | KMT2AMEN1MAPK8MAPK9CDK2 | |
| SCHEMBL5867452 | 0.83 | MTNR1A (0.54) | SIGMAR1HSD17B10KMT2AMEN1RAB9A | |
| SCHEMBL5867989 | 0.83 | ALPL (0.55) | GLSSIGMAR1KMT2AMEN1CDK2 | |
| SCHEMBL5868067 | 0.82 | CDK2 (0.67) | GLSSIGMAR1KMT2AMEN1MAPK8 | |
| SCHEMBL6390325 | 0.81 | CDK2 (0.46) | GLSKMT2AMEN1CDK2CDK9 | |
| SCHEMBL5867660 | 0.81 | CFTR (0.44) | SIGMAR1KMT2AMEN1CDK2CCNA2 | |
| SCHEMBL5868099 | 0.81 | CDK2 (0.69) | CDK2CCNA2CCNA1CDK9CDK5 | |
| SCHEMBL13376907 | 0.80 | GLS (0.48) | GLSAURKAAURKBHSD17B10KMT2A | |
| SCHEMBL7920085 | 0.79 | NPC1 (0.50) | AURKBHSD17B10KMT2AMEN1CDK2 | |
| SCHEMBL5868042 | 0.76 | CCNA2 (0.63) | KMT2AMEN1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034049-B1 | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents | PHARMACIA ITALIA S.P.A. (IT) | 2006-04-25 | — | — | US | disclosed |
| EP-1202733-B1 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-10-05 | — | — | EP | disclosed |
| EP-1202733-A4 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2003-05-14 | — | — | EP | disclosed |
| EP-1202733-A1 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-05-08 | — | — | EP | disclosed |
| US-6218418-B1 | THERAPY OF CELL PROLIFERATIVE DISORDERS ASSOCIATED WITH AN ALTERED CELL DEPENDENT KINASE ACTIVITY BY ADMINISTERING AMINO PYRAZOLE DERIVATIVE TO MAMMAL | PHARMACIA & UPJOHN S.P.A (IT) | 2001-04-17 | — | — | US | disclosed |
| WO-2001012189-A1 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-02-22 | — | — | WO | disclosed |