SCHEMBL5867902

SCHEMBL5867902

CCOc1ccccc1C(=O)Nc1cc(C2CC2)n[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.49
MAPK1 P28482 3/20 0.49
RXFP1 Q9HBX9 3/20 0.49
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
GAA P10253 3/20 0.49
ALOX15 P16050 2/20 0.49
KCNMA1 Q12791 2/20 0.49
TSHR P16473 2/20 0.49
USP2 O75604 1/20 0.49
TP53 P04637 1/20 0.49
KCNK3 O14649 1/20 0.49
KCNK9 Q9NPC2 1/20 0.49
POLB P06746 1/20 0.48
HCRTR1 O43613 1/20 0.48
MRGPRX1 Q96LB2 1/20 0.47
LMNA P02545 2/20 0.47
ALDH1A1 P00352 1/20 0.47
KDM4E B2RXH2 1/20 0.47
HPGD P15428 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5867557 0.87 KCNK3 (0.50) MAPTMAPK1RXFP1MEN1KMT2A
SCHEMBL5867690 0.81 CRACR2A (0.52) MEN1KMT2AALOX15KCNMA1KCNK3
SCHEMBL5597704 0.81 LMNA (0.51) MAPTMAPK1MEN1KMT2AGAA
SCHEMBL5867821 0.80 CCNA2 (0.65) RXFP1
SCHEMBL5867482 0.80 CCNA2 (0.64) MAPTKMT2AGAATSHRTP53
SCHEMBL5867534 0.79 CCNA2 (0.62) MAPTMEN1KMT2ATSHRLMNA
SCHEMBL5867402 0.77 MMP3 (0.48) MEN1KMT2APOLBALDH1A1
SCHEMBL5867567 0.77 HSD11B1 (0.57) MAPK1MEN1KMT2APOLBALDH1A1
SCHEMBL7920085 0.76 NPC1 (0.50) MAPTMEN1KMT2AGAATSHR
SCHEMBL7921227 0.76 ALDH1A1 (0.52) MAPTKMT2AGAATP53POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7034049-B1 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents PHARMACIA ITALIA S.P.A. (IT) 2006-04-25 US disclosed
EP-1202733-B1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-10-05 EP disclosed
EP-1202733-A4 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2003-05-14 EP disclosed
CN-1373662-A 3(5)-amino-pyrazole derivs., process for their preparation and their use as antitumor agents PHARMACIA & UP JOHN S P A (IT) 2002-10-09 CN disclosed
EP-1202733-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2002-05-08 EP disclosed
US-6218418-B1 THERAPY OF CELL PROLIFERATIVE DISORDERS ASSOCIATED WITH AN ALTERED CELL DEPENDENT KINASE ACTIVITY BY ADMINISTERING AMINO PYRAZOLE DERIVATIVE TO MAMMAL PHARMACIA & UPJOHN S.P.A (IT) 2001-04-17 US disclosed
WO-2001012189-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA S.P.A. (IT) 2001-02-22 WO disclosed