Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 1/20 | 0.59 |
| ▸ | PYGL | P06737 | 12/20 | 0.58 |
| ▸ | PYGM | P11217 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913156 | 0.91 | PYGL (0.57) | HPSEPYGLPYGMMAPTKDM4E | |
| SCHEMBL6632890 | 0.82 | TP53 (0.68) | HPSEMAPTKDM4EMEN1ALDH1A1 | |
| 2-Benzoylbenzoic Acid SCHEMBL27616766 | 0.81 | AKR1C3 (0.65) | HPSEKDM4EAKR1C3 | |
| SCHEMBL7823632 | 0.81 | KDM4E (0.55) | PYGLPYGMMAPTKDM4EALDH1A1 | |
| SCHEMBL28087984 | 0.78 | SRD5A2 (0.58) | HPSEMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL7598127 | 0.78 | SMN1; SMN2 (0.53) | PYGLPYGMMAPTMEN1ALDH1A1 | |
| SCHEMBL11453175 | 0.77 | LMNA (0.57) | MAPTKDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL4452102 | 0.76 | KMT2A (0.55) | HPSEPYGLPYGMMAPTKDM4E | |
| SCHEMBL9768792 | 0.76 | KDM4E (0.56) | HPSEPYGLPYGMMAPTKDM4E | |
| SCHEMBL921873 | 0.76 | AKR1C3 (0.69) | PYGMKDM4EALDH1A1KMT2AAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291442-B1 | Pharmacological modulators of voltage-gated potassium ion channels | THE GENERAL HOSPITAL CORPORATION | 2001-09-18 | — | — | US | claimed |