Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PYGL | P06737 | 13/20 | 0.54 |
| ▸ | PYGM | P11217 | 3/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752469 | 0.91 | MAPT (0.54) | KDM4EPYGLPYGMPLAUALDH1A1 | |
| SCHEMBL17819637 | 0.89 | PYGL (0.54) | KDM4EPYGLPYGMPLAUALDH1A1 | |
| SCHEMBL7913156 | 0.89 | PYGL (0.57) | KDM4EPYGLPYGMALDH1A1TDP1 | |
| SCHEMBL17037019 | 0.84 | MEN1 (0.71) | PYGLPYGMPLAUALDH1A1TDP1 | |
| SCHEMBL2820914 | 0.82 | ALDH1A1 (0.50) | PYGLPLAUALDH1A1CYP3A4ALOX15 | |
| 2-Benzoylbenzoic Acid SCHEMBL7920095 | 0.81 | HPSE (0.59) | KDM4EPYGLPYGMALDH1A1TP53 | |
| SCHEMBL5214063 | 0.79 | MAPT (0.57) | KDM4EALDH1A1CYP3A4ALOX15TDP1 | |
| SCHEMBL7706101 | 0.79 | HTT (0.58) | KDM4EALDH1A1CYP3A4TDP1MAPT | |
| SCHEMBL11453175 | 0.78 | LMNA (0.57) | KDM4EALDH1A1CYP3A4ALOX15TDP1 | |
| SCHEMBL17820557 | 0.78 | TBXA2R (0.51) | PYGLPYGMPLAUALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291442-B1 | Pharmacological modulators of voltage-gated potassium ion channels | THE GENERAL HOSPITAL CORPORATION | 2001-09-18 | — | — | US | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |