Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924679 | 0.91 | TAAR1 (0.35) | CYP1A2CYP2C19MEN1LMNAKMT2A | |
| SCHEMBL7921745 | 0.87 | F2R (0.38) | CYP1A2CYP2C19SMN1; SMN2MEN1LMNA | |
| SCHEMBL7911135 | 0.87 | ALDH1A1 (0.34) | CYP1A2CYP2C19SMN1; SMN2MEN1LMNA | |
| SCHEMBL7922030 | 0.86 | ALDH1A1 (0.34) | CYP1A2CYP2C19SMN1; SMN2MEN1LMNA | |
| SCHEMBL12230553 | 0.80 | HPGD (0.39) | CYP1A2CYP2C19SMN1; SMN2MEN1LMNA | |
| SCHEMBL7923388 | 0.77 | CYP1A2 (0.36) | CYP1A2CYP2C19SMN1; SMN2MEN1LMNA | |
| SCHEMBL12203757 | 0.76 | SMN1; SMN2 (0.37) | CYP1A2CYP2C19SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12203761 | 0.76 | SMN1; SMN2 (0.37) | CYP1A2CYP2C19SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12203758 | 0.76 | SMN1; SMN2 (0.37) | CYP1A2CYP2C19SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12203763 | 0.73 | KDM4E (0.35) | SMN1; SMN2ALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042475-A1 | SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |