SCHEMBL7920300

SCHEMBL7920300

CO[Si](CCCOc1ccc(-c2ccc(OC#N)cc2)cc1)(OC)OC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.41
CYP2D6 P10635 2/20 0.41
HRH3 Q9Y5N1 9/20 0.38
HRH1 P35367 8/20 0.38
HRH2 P25021 7/20 0.38
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 2/20 0.38
HPGD P15428 2/20 0.38
HTT P42858 1/20 0.38
MEN1 O00255 1/20 0.38
MAPT P10636 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MCHR1 Q99705 1/20 0.38
MMP2 P08253 2/20 0.37
CYP19A1 P11511 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
LSS P48449 1/20 0.36
MMP3 P08254 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3027168 0.86 HRH3 (0.51) HRH3HRH1HRH2ALDH1A1KDM4E
SCHEMBL7916849 0.85 CYP2D6 (0.43) CYP3A4CYP2D6HRH3HRH1HRH2
SCHEMBL7920348 0.81 CYP3A4 (0.44) CYP3A4CYP2D6HRH3HRH1HRH2
SCHEMBL14632314 0.78 MAPT (0.50) HRH3ALDH1A1HPGDMEN1MAPT
SCHEMBL7917007 0.78 CALM1 (0.41) ALDH1A1L3MBTL1CYP19A1
SCHEMBL7132447 0.75 DRD2 (0.52) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL26246281 0.75 ACACB (0.40) CYP2D6HRH3ALDH1A1KDM4EHPGD
SCHEMBL7916812 0.74 TAAR1 (0.39) ALDH1A1KDM4EMAPT
SCHEMBL13223915 0.74 ESR2 (0.52) CYP3A4ALDH1A1KDM4EHPGDMEN1
SCHEMBL8015992 0.74 TDP1 (0.50) CYP3A4ALDH1A1KDM4EHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6217943-B1 ADHESION AND REINFORCEMENT WITH SILANE CYANATE COUPLERS 3M INNOVATIVE PROPERTIES COMPANY 2001-04-17 US disclosed
US-5912377-A CONTAINING AT LEAST ONE CYANATE ESTER GROUP AND HYDROLYZABLE SILYL GROUP; REINFORCED COMPOSITES, ADESIVES, COATINGS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1999-06-15 US disclosed
EP-0830410-B1 AROMATIC CYANATE ESTER SILANE COUPLING AGENTS MINNESOTA MINING & MFG (US) 1999-04-07 EP disclosed
EP-0830410-A1 AROMATIC CYANATE ESTER SILANE COUPLING AGENTS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-03-25 EP disclosed
WO-1996039457-A1 AROMATIC CYANATE ESTER SILANE COUPLING AGENTS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-12-12 WO disclosed