SCHEMBL7920540

SCHEMBL7920540

COC(=O)c1c(C(F)(F)F)ccc(F)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 4/20 0.45
HTT P42858 1/20 0.43
PDK2 Q15119 3/20 0.40
MRGPRX4 Q96LA9 2/20 0.39
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
MEN1 O00255 1/20 0.38
MAPT P10636 1/20 0.38
CASP3 P42574 1/20 0.38
KMT2A Q03164 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
CFTR P13569 2/20 0.37
HSP90AA1 P07900 1/20 0.36
HSP90B1 P14625 1/20 0.36
TMPRSS4 Q9NRS4 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29256623 0.87 NOTUM (0.45) NOTUMHTTPDK2MRGPRX4CA12
SCHEMBL7929881 0.85 NOTUM (0.46) NOTUMHTTMRGPRX4CA12CA1
SCHEMBL7932574 0.85 NOTUM (0.49) NOTUMHTTMRGPRX4CA12CA1
SCHEMBL7927649 0.83 NOTUM (0.47) NOTUMHTTMRGPRX4CA12CA1
SCHEMBL8157649 0.83 ALDH1A1 (0.47) PDK2CA12CA1CA2CA7
SCHEMBL28172626 0.80 KCNQ3 (0.37) HTTTMPRSS4KIF11
SCHEMBL7932556 0.80 KMO (0.40) NOTUMKIF11
SCHEMBL7920532 0.78 F2 (0.37) HTTPDK2MAPTKDM4EKIF11
SCHEMBL21435217 0.77 ABL1 (0.47) PDK2CA12CA1CA2CA7
SCHEMBL8493814 0.77 CFTR (0.47) NOTUMPDK2MRGPRX4CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0847977-B1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO (JP) 2001-08-29 EP disclosed
US-6054624-A USEFUL AS THE STARTING MATERIALS FOR PRODUCING PESTICIDES, DRUGS AND THE LIKE NIPPON SODA CO., LTD. (JP) 2000-04-25 US disclosed
US-6054605-A CHEMICAL INTERMEDIATE FOR DRUGS, PESTICIDES NIPPON SODA CO., LTD. (JP) 2000-04-25 US disclosed
EP-0847977-A1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO., LTD. (JP) 1998-06-17 EP disclosed