Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30258234 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HTTLMNAMAPK1RAB9A | |
| SCHEMBL56332 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HTTLMNAMAPK1RAB9A | |
| Hydrochloric Acid SCHEMBL1137081 | 0.98 | ALDH1A1 (0.47) | ALDH1A1HTTLMNAMAPK1RAB9A | |
| Pyrimidine SCHEMBL27956767 | 0.93 | ALDH1A1 (0.47) | ALDH1A1HTTLMNAMAPK1RAB9A | |
| SCHEMBL827098 | 0.83 | MAPK1 (0.48) | ALDH1A1HTTLMNAMAPK1RAB9A | |
| SCHEMBL8568179 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HTTLMNAMAPK1RAB9A | |
| Ethylene SCHEMBL27749127 | 0.77 | ALDH1A1 (0.50) | ALDH1A1HTTLMNAMAPK1RAB9A | |
| SCHEMBL619318 | 0.76 | MAPT (0.52) | ALDH1A1HTTLMNAMAPK1MEN1 | |
| SCHEMBL6973083 | 0.76 | MAPT (0.56) | ALDH1A1HTTLMNAMAPK1MEN1 | |
| SCHEMBL10734254 | 0.75 | ALDH1A1 (0.49) | ALDH1A1HTTLMNAMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932405-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORP (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-0932405-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1997049400-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |