Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323199 | 1.00 | HDAC3 (0.48) | HDAC3HDAC1HDAC2ALDH1A1MEN1 | |
| SCHEMBL1342037 | 0.98 | HDAC3 (0.46) | HDAC3HDAC1HDAC2ALDH1A1MEN1 | |
| SCHEMBL5278682 | 0.87 | KEAP1 (0.54) | HDAC3HDAC1HDAC2ALDH1A1MEN1 | |
| SCHEMBL1342200 | 0.85 | KEAP1 (0.56) | HDAC3HDAC1HDAC2ALDH1A1MEN1 | |
| SCHEMBL5285314 | 0.81 | AAK1 (0.49) | HDAC3HDAC1HDAC2MEN1KMT2A | |
| SCHEMBL5278117 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2ARAB9ALMNA | |
| SCHEMBL3909614 | 0.81 | KMT2A (0.47) | HDAC3HDAC1HDAC2ALDH1A1MEN1 | |
| SCHEMBL5326393 | 0.80 | KDM4E (0.58) | ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL1340751 | 0.79 | ERCC1 (0.36) | HDAC3HDAC1HDAC2ALDH1A1MEN1 | |
| SCHEMBL5326364 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ARAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294580-B1 | FOR THERAPY AND PROPHYLAXIS OF TYPE II OR NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERGLYCAEMIA, DYSLIPIDEMIA, TYPE II DIABETES, TYPE I DIABETES, HYPERTRIGLYCERIDEMIA, SYNDROME X, INSULIN RESISTANCE, HEART FAILURE | GLAXO WELLCOME INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0888317-B1 | SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA | GLAXO GROUP LTD (GB) | 2001-09-12 | — | — | EP | disclosed |