Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857398 | 0.87 | KDM4E (0.54) | AAK1KDM4EGLARAB9AATM | |
| SCHEMBL1340593 | 0.85 | KDM4E (0.56) | AAK1KDM4EGLARAB9AATM | |
| SCHEMBL3909614 | 0.81 | KMT2A (0.47) | RAB9AMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL5278117 | 0.81 | ALDH1A1 (0.52) | KDM4ERAB9AMEN1KMT2A | |
| SCHEMBL7920995 | 0.81 | HDAC3 (0.48) | RAB9AMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL5323199 | 0.81 | HDAC3 (0.48) | RAB9AMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL1260625 | 0.80 | CES2 (0.43) | KDM4ERAB9AMAPTPOLBNPC1 | |
| SCHEMBL5326364 | 0.79 | ALDH1A1 (0.50) | KDM4ERAB9AMEN1KMT2A | |
| SCHEMBL17997263 | 0.79 | DGAT1 (0.54) | RAB9AKMT2AMAPTPOLBNPC1 | |
| SCHEMBL1259126 | 0.79 | POLB (0.38) | AAK1RAB9AATMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |