SCHEMBL7921280

SCHEMBL7921280

COc1c(F)c2c(c(F)c1Nc1c(Cl)cccc1Cl)C(=O)c1c(O)ccc(O)c1C2=O

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.45
PIM1 P11309 1/20 0.45
AR P10275 3/20 0.40
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
HSD17B1 P14061 1/20 0.36
HSD17B2 P37059 1/20 0.36
MAPT P10636 1/20 0.35
MAOA P21397 1/20 0.35
IDO1 P14902 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7921206 0.93 EGFR (0.41) EGFRPIM1AR
SCHEMBL7933254 0.86 MAPT (0.39) EGFRPIM1MEN1KMT2AMAPT
SCHEMBL7927337 0.86 EGFR (0.46) EGFRPIM1MEN1KMT2AMAPT
SCHEMBL7927152 0.84 MEN1 (0.40) EGFRPIM1MEN1KMT2AMAPT
SCHEMBL7921338 0.84 MAPT (0.37) EGFRPIM1MEN1KMT2AMAPT
SCHEMBL7930637 0.84 EGFR (0.44) EGFRPIM1MEN1KMT2AMAPT
SCHEMBL7928355 0.83 ELANE (0.37) EGFRPIM1MEN1KMT2AMAPT
SCHEMBL7930388 0.82 ELANE (0.37) EGFRPIM1MEN1KMT2A
SCHEMBL7921426 0.82 PIM1 (0.40) EGFRPIM1MEN1KMT2AHSD17B1
SCHEMBL7929769 0.80 PTGS2 (0.41) EGFRPIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0661350-B1 Quinizarin compound, method for production thereof, and use therefor NIPPON CATALYTIC CHEM IND (JP) 2001-08-22 EP disclosed
US-5817843-A Quinizarin compound, method for production thereof, and use therefor NIPPON SHOKUBAI CO., LTD. (JP) 1998-10-06 US disclosed
US-5608091-A SHEETS FOR HEAT EXCHANGING AND OPTICAL RECORDING MATERIAL NIPPON SHOKUBAI CO., LTD. (JP) 1997-03-04 US disclosed
EP-0661350-A1 Quinizarin compound, method for production thereof, and use therefor NIPPON SHOKUBAI CO., LTD. (JP) 1995-07-05 EP disclosed